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Finding missense variants that help explain the differences in dentition in Neanderthals and modern humans using a multiple sequence alignment (R seqinr and msa package).
Pax9 is a gene belonging to the family of paired-box genes that encode transcription factors involved in organogenesis. Defects in Pax9 can lead to various types of cancer as well as a condition known as oligodontia which causes missing teeth in individuals. A random forest model was used to predict the phenotypic effect of variants of PAX9.